Cystic Fibrosis home | Documents | Photo|

 

On June 5-6th was held in Angers (France) the third meeting of our working group on Fungal respiratory infections in Cystic Fibrosis. This meeting coming from 13 countries, including the USA and Australia, and for the first time in our meeting from Sweden, Poland and Slovenia. During the meeting which comprised 74 attendants, 35 talks were given covering all topics from clinical surveillance, biological diagnosis and antifungal resistance and treatment, to pathogenesis of the airway colonization/respiratory infections, or epidemiology and ecology of the pathogens, and several collaborative works were presented. For more information about the meeting and our working group, please download the abstract book and the updated list of members.

 

Programme Third meeting 2014

For Presentations Third meeting 2014 click here

Thursday, June 5th

  • 13 h: Welcome Reception
  • 13 h 45: Introduction Talk – Jean-Philippe Bouchara – Prof. Olivier Duval (Head of the Faculty of Pharmacy) – Prof. Isabelle Richard (Head of the Faculty of Medicine)

14 h 00 – 16 h 15: Clinical aspects (Prof. Javier Pemán, Valencia, Spain)

  • 14 h 00 – 14 h 15:
    Organization of patient management and epidemiology of fungal infections in CF in Poland
    Ewa Romanowska, Hanna Dmeńska, Magdalena Kołodziejczyk, Alicja Pawińska and Katarzyna Dzierżanowska-Fangrat (Warsaw, Poland)
  • 14 h 15 – 14 h 30:
    Aspergillus sensitization and carriage in cystic fibrosis patients
    Judith Fillaux, François Brémont, Marlène Murris, Sophie Cassaing, Laurent Tétu, Christine Segonds, Bernard Pipy and Jean-François Magnaval (Toulouse, France)
  • 14 h 30 – 14 h 45:
    The Scedosporium apiospermum species complex: seroprevalence in patients with cystic fibrosis and clinical relevance
    Stéphane Durupt, Perrine Parize, Sandrine Billaud, Anne-Lise Bienvenu, Raymond Robert, Stéphane Picot, Olivier Lortholary, Jean-Philippe Bouchara and Isabelle Durieu (Lyon, France)
  • 14 h 45 – 15 h 00:
    Colonization by Rasamsonia argillacea in cystic fibrosis patients: a 5-year retrospective study
    Ersilia Fiscarelli, Arianna Biffi, Gabriella Ricciotti, Vanessa Tuccio, Martina Rossitto, Davide Guarneri and Lisa Cariani (Roma and Milano, Italy)
  • 15 h 00 – 15 h 20:
    Chronic infections by Trichosporon mycotoxinivorans in cystic fibrosis patients, management implications and literature review
    Patrick W. Hickey and Andrew J. Lipton (Bethesda, USA)
  • 15 h 20 – 15 h 40:
    Epidemiological and clinical aspects of Trichosporon mycotoxinivorans isolation in patients with cystic fibrosis
    Kathrin Tintelnot, Andrea Haas, Friedrich-Karl Tegtmeyer, Michael Klotz, Christoph Runge, Michael Seibold, Carsten Müller, Ludwig Sedlacek and Carsten Schwarz (Berlin, Germany)
  • 15 h 40 – 16 h 00:
    Development of IgG antibodies to Exophiala dermatitidis is associated with inflammatory responses in patients with cystic fibrosis
    Nahid Kondori, Anders Lindblad, Christine Wennerås, Christina Welinder-Olsson, Marita Gilljam and Edward Moore (Gothenbourg, Sweden)
  • 16 h 00 – 16 h 15:
    Exophiala colonization as a surrogate marker for cystic fibrosis in the elderly
    Frédéric Grenouillet, Bénédicte Richaud-Thiriez, Laurence Millon and Jean-Charles Dalphin (Besançon, France)

16 h 15 – 16 h 45: Coffee break

16 h 45 – 18 h 30: Antifungal susceptibility and treatment (Dr. Françoise Symoens, Brussels, Belgium)

  • 16 h 45 – 17 h 05:
    Epidemiology of azole-resistant Aspergillus fumigatus in Germany
    Anna Dudakova, Aline Wehr, Michael Weig, Uwe Gross and Oliver Bader (Göttingen, Germany)
  • 17 h 05 – 17 h 20:
    Emergence of Aspergillus fumigatus isolates resistant to azole drugs in lung transplant recipients with cystic fibrosis
    Firas Choukri, Florent Morio, Romain Guillemain, Véronique Boussaud, Catherine Amrein, Eliane Billaud, Patrice Le Pape, Jacques Guillot, Françoise Botterel and Eric Dannaoui (Créteil, France)
  • 17 h 20 – 17 h 40:
    Molecular characterization of azole resistance in Aspergillus spp. isolates from cystic fibrosis patients from Cologne
    Axel Hamprecht, J. Fischer, Silke van Koningsbruggen-Rietschel, Ernst Rietschel, Maria J.G.T. Vehreschild, Hilmar Wisplinghoff and Martin Krönke (Köln, Germany)
  • 17 h 40 – 17 h 55:
  • Persistence of azole-resistant Aspergillus fumigatus in cystic fibrosis patients after azole discontinuation
    André Paugam, Dominique Hubert, Reem Kanaan, Jeanne Chapron, Isabelle Honoré, Ferry Hagen, Jacques F. Meis and Pierre-Régis Burgel (Paris, France)
  • 17 h 55 – 18 h 10:
    The emergence of resistance in opportunistic fungal pathogens: a collateral damage of the use of pesticides in the environment?
    Jacques Guillot, Pascal Arné, René Chermette, Firas Choukri, Françoise Botterel and Eric Dannaoui (Créteil, France)
  • 18 h 10 – 18 h 30:
    Successful prevention of scedosporiosis after lung transplantation in a cystic fibrosis patient by combined local and systemic triazole therapy
    Carolin Hartmann, Carsten Müller, Hartmut Weißbrodt, Sebastian Suerbaum, Kathrin Tintelnot, Stefan Stolle, Gesine Hansen and Ludwig Sedlacek (Hannover, Germany)

19 h 15: Visit of the Museum David d'Angers and dinner

Friday, June 6th

  • 9 h 00 - 10 h 35:
    Pathogenesis of fungal airway colonization/respiratory infections in CF (Prof. Craig Williams, Glasgow, United Kingdom)
  • 9 h 00 – 9 h 20:
    Mixed species biofilms of Pseudomonas aeruginosa and Aspergillus fumigatus alter the pathogenicity of each component
    Karen Smith, Gordon Ramage, Gordon MacKay and Craig Williams (Glasgow, United Kingdom)
  • 9 h 20 – 9 h 40:
    Development and antimicrobial susceptibility studies of in vitro monomicrobial and polymicrobial biofilm models with Aspergillus fumigatus and Pseudomonas aeruginosa
    José A. Vazquez, Dora L. Vager and Elias K. Manavathu (Augusta, USA)
  • 9 h 40 – 10 h 00:
    Antifungal activity of Myriocin, a sphingolipid metabolism inhibitor, on fungal biofilms
    Federica Perdoni, Daniela Cirasola, Valentina Galimberti, Marco Biggiogera, Anna Caretti, Paola Signorelli, Giulia Morace and Elisa Borghi (Milan, Italy)
  • 10 h 00 – 10 h 15:
    Fungal lectins: targets for anti-adhesive therapy
    Soorej M. Basheer, Doerte Hundling, Josef Houser, Aymeric Audfray, Valérie Chazalet, Markus Künzler, Agnès Marot, Anne Imberty, Michaela Wimmerova and Annabelle Varrot (Grenoble, France)
  • 10 h 15 – 10 h 35:
    Characterization and pathogenicity of Exophiala dermatitidis from CF
    Maike Olsowski, Peter-Michael Rath and Joerg Steinmann (Essen, Germany)

10 h 35 - 11 h 00: Coffee break

11 h 00 – 13 h 00: Biological diagnosis (Dr. Laurence Delhaès, Lille, France)

  • 11 h 00 – 11 h 15:
    Enhanced routine clinical filamentous fungi identification via MALDI-TOF Mass Spectrometry at the University hospital of Marseille
    Anne-Cécile Normand, Magali Gautier, Carole Cassagne, Coralie L'Ollivier, Stéphane Ranque and Renaud Piarroux (Marseille, France)
  • 11 h 15 – 11 h 30:
    MALDI-TOF Mass Spectrometry analysis of the fungal diversity in the environment and respiratory samples of Cystic Fibrosis patients
    Anne-Cécile Normand, Magali Gautier, Aurélie Sapet-Hajost, Carole Cassagne, Stéphane Ranque and Renaud Piarroux (Marseille, France)
  • 11 h 30 – 11 h 45:
    Rasamsonia species isolated from cystis fibrosis patients: MALDI-TOF/MS identification and antifungal susceptibility by EUCAST method
    Stéphanie Jacob, Sandrine Giraud, Eric Dannaoui, Julie Léto, Abdelmounaim Mouhajir, Cécile Angebault, Jean-Luc Béretti, Loïc Favennec, Jean-Philippe Bouchara and Marie-Elisabeth Bougnoux (Paris, France)
  • 11 h 45 – 12 h 00:
    Lung mycobiota from patients with cystic fibrosis: Recent updates and links with other microbial communities
    Laurence Delhaès, Linh Nguyen Do Ngoc, Emilie Sitterlé, Eric Viscogliosi and Françoise Botterel (Lille, France)
  • 12 h 00 – 12 h 20:
    Evaluation of a novel real-time PCR for detecting Rasamsonia argillacea species complex in respiratory secretions from CF patients
    Joerg Steinmann, Sandrine Giraud, Dirk Schmidt, Ludwig Sedlacek, Axel Hamprecht, Jos Houbraken, Jacques Meis, Jean-Philippe Bouchara, Jan Buer and Peter-Michael Rath (Essen, Germany)
  • 12 h 20 – 12 h 40:
    Routine processing procedures for isolating filamentous fungi from respiratory sputum samples may underestimate fungal prevalence
    Catherine Pashley and Andrew Wardlaw (Leicester, United Kingdom)
  • 12 h 40 – 13 h 00:
    Fungus-reactive T cells as sensitive and specific sensors to diagnose fungal infections in cystic fibrosis patients
    Carsten Schwarz, Petra Bacher, Anja Thronicke, Claudia Brandt, Kathrin Tintelnot and Alexander Scheffold (Berlin, Germany)

13 h 00 - 14 h 15: Lunch at the Faculty

14 h 15 – 16 h 05: Epidemiology of fungal respiratory infections and ecology of the pathogens (Prof. José F. Cano, Reus, Spain)

  • 14 h 15 – 14 h 35:
    Epidemiology of moulds isolated from cystic fibrosis patients in one Spanish Hospital
    Ana Alastruey-Izquierdo, Sara Gago, Jorge Guitán, Amparo Solé and Javier Pemán (Majadahonda, Spain)
  • 14 h 35 – 14 h 55:
    Patterns of Aspergillus fumigatus colonisation and antifungal drug susceptibility in Irish Cystic Fibrosis Patients
    Katie Dunne, Julie Renwick, Gerard McElvaney, Sanjay Chotirmall, Ferry Hagen, Jacques F. Meis, Philip Murphy and Thomas R Rogers (Dublin, Ireland)
  • 14 h 55 – 15 h 10:
    Sequential variations of Rasamsonia spp. isolate genotypes in cystic fibrosis patients
    Olivier Matray, Abdelmounaim Mouhajir, Sandrine Giraud, Gilles Gargala, Rachid Zouhair, Marie-Elisabeth Bougnoux, Jean-Philippe Bouchara, and Loïc Favennec (Rouen, France)
  • 15 h 10 – 15 h 30:
    Black yeast Exophiala dermatitidis and other human fungal pathogens inhabit different domestic environments – from dishwashers to kitchen surfaces
    Nina Gunde-Cimerman and Polona Zalar (Ljubljana, Slovenia)
  • 15 h 30 – 15 h 50:
    Dishwashers provides an extreme environment for several opportunistic fungal pathogens, particularly for black yeasts
    Ramazan Gümral, Betil-Özhak Baysan, Ayşegül Tümgör, Mehmet Ali Saraçli, Şinasi Taner Yildiran, Macit Ilkit and G. Sybren de Hoog (Adana, Turkey)
  • 15 h 50 – 16 h 05:
    Human-impacted areas of France are environmental reservoirs of the Scedosporium apiospermum species complex
    Amandine Rougeron, Gaëlle Schuliar, Julie Léto, Emilie Sitterlé, David Landry, Marie-Elisabeth Bougnoux, Abdessamad Kobi, Jean-Philippe Bouchara and Sandrine Giraud (Bordeaux, France)

16 h 05 – 16 h 35: Coffee break

16 h 35 – 17 h 45: Genomic tools for studies on pathogenesis

  • 16 h 35 – 16 h 50:
    Use of ribosomal introns as new markers of genetic diversity in Exophiala dermatitidis
    Marie Machouart, Cécile Gueidan, Montarop Sudhadham and Sybren De Hoog (Nancy, France)
  • 16 h 50 – 17 h 05:
    Cell wall changes during maturation of conidia in Scedosporium boydii
    Sarah Ghamrawi, Gilles Renier, Patrick Saulnier, Stéphane Cuénot, Agata Zykwinska, Bas E. Dutilh, Christopher Thornton, Sébastien Faure and Jean-Philippe Bouchara (Angers, France)
  • 17 h 05 – 17 h 25:
    Genome analysis of Scedosporium aurantiacum
    Wieland Meyer, Åsa Pérez-Bercoff, Marc Ramsperger, Carolina Firacative, A. Papanicolau, H.R. Patel, Liam D.H. Elbourne, Gavin A. Huttley and Helena Nevalainen (Sydney, Australia)
  • 5 min: Genome sequencing of Peudallescheria minutispora Laurence Delhaès (Lille, France)
    5 min: Complete genome sequence of Scedosporium apiospermum Patrick Vandeputte (Angers, France)
    5 min: Gene disruption in Scedosporium species – Sandrine Giraud (Angers, France)
    5 min: Recombinant proteins for serodiagnosis of scedosporiosis – Maxime Fleury (Angers, France)

17 h 45 – 18 h 30: Other potential projects to be discussed (Prof. Jean-Philippe Bouchara, Angers, France – Dr. Françoise Symoens, Brussels, Belgium)

  • Clinical significance of long-term colonization by rare mould species – Judith Fillaux (Toulouse, France)
  • Guidelines for mycological examination of sputum samples from patients with CF – Laurence Delhaès (Lille, France)
  • A new qPCR tool to assess Exophiala colonization in cystic fibrosis patients and validation of PCR detection methods for Exophiala dermatitidis (and Rasamsonia species) – Frédéric Grenouillet (Besançon, France)
  • Epidemiology of Rasamsonia species
  • Special issue highlighting our research topic
  • The MICROBE platform project of Angers University / Angers University Hospital – Jean-Philippe Bouchara (Angers, France)

18 h 45: End of the meeting